Pub. Date : 2015 May 5
PMID : 25724548
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling. | ros | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Specifically, we demonstrated that benzo[a]pyrene enhances breast cancer cell migration and invasion by up-regulating ROS-induced ERK signaling, leading to the activation of matrix metalloproteinases 9. | ros | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Our results suggest that benzo[a]pyrene-induced mammary gland cancer metastasis is an important and intricate process facilitated by cumulative benzo[a]pyrene exposure leading to activation of the ROS-ERK-MMP9 signaling pathway. | ros | mitogen-activated protein kinase 1 | Homo sapiens |