Pub. Date : 2015 Jun
PMID : 25724470
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nimesulide also induced apoptosis, which was accompanied by a significant decrease in the expression of COX-2 and survivin and an increase in caspase-3 expression. | nimesulide | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Nimesulide downregulated the phosphorylation levels of JAK2 and STAT3, and JAK2 inhibition by AG490 significantly augmented both nimesulide-induced apoptosis and the downregulation of COX-2 and survivin (P<0.05). | nimesulide | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Thus, nimesulide downregulates COX-2 and survivin expression and upregulates caspase-3 expression in Eca-109 cells, by inactivating the JAK2/STAT3 pathway. | nimesulide | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |