Title : Altered esophageal histamine receptor expression in Eosinophilic Esophagitis (EoE): implications on disease pathogenesis.

Pub. Date : 2015

PMID : 25723478






2 Functional Relationships(s)
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1 H1R and H2R, but not H3R or H4R, were constitutively expressed by primary and immortalized cells, and epithelial histamine stimulation induced GM-CSF, TNFalpha, and IL-8, but not TSLP or eotaxin-3 secretion. Histamine tumor necrosis factor Homo sapiens
2 Epithelial priming with the TLR3 ligand poly (I:C) induced H1R and H2R expression, and enhanced histamine-induced GM-CSF, TNFalpha, and IL-8 secretion. Histamine tumor necrosis factor Homo sapiens