Pub. Date : 2015 Apr 28
PMID : 25720435
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-kappaB signalling pathway in human epidermoid carcinoma A431 cells. | shikonin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | In addition, shikonin evidently induced apoptosis due to decreasing Bcl-2 expression, increasing Bax expression, activating caspase and inactivating NF-kappaB, while pretreatment with a pan-caspase inhibitor Z-Asp-CH2-DCB abrogated shikonin-induced apoptosis. | shikonin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Moreover, EGF could significantly increase the NF-kappaB DNA-binding activity and reversed the shikonin-induced inactivation of NF-kappaB. | shikonin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | As anticipated AG1478 (EGFR inhibitor) and Bay11-7082 (NF-kappaB inhibitor) blocked EGF-reversed the inactivation of NF-kappaB induced by shikonin. | shikonin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | As anticipated AG1478 (EGFR inhibitor) and Bay11-7082 (NF-kappaB inhibitor) blocked EGF-reversed the inactivation of NF-kappaB induced by shikonin. | shikonin | nuclear factor kappa B subunit 1 | Homo sapiens |