Title : Chlorogenic acid enhances the effects of 5-fluorouracil in human hepatocellular carcinoma cells through the inhibition of extracellular signal-regulated kinases.

Pub. Date : 2015 Jun

PMID : 25714249






2 Functional Relationships(s)
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1 A previous report has shown that ROS are upstream mediators that inactivate ERK in hepatocellular carcinoma cells. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens
2 Combined with our results, this indicates that the combination of 5-FU and CGA leads to the inactivation of ERK through the overproduction of ROS. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens