Pub. Date : 2015 Apr 10
PMID : 25713071
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Cyclic AMP signaling reduces sirtuin 6 expression in non-small cell lung cancer cells by promoting ubiquitin-proteasomal degradation via inhibition of the Raf-MEK-ERK (Raf/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase) pathway. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
2 | It is concluded that cAMP signaling reduces SIRT6 expression by promoting its ubiquitin-proteasome-dependent degradation, a process mediated by the PKA-dependent inhibition of the Raf-MEK-ERK pathway. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |