Pub. Date : 2015 May
PMID : 25712788
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we report that breast cancer nodules in mice can be effectively treated by preconditioning the tumors with 1alpha, 25-dihydroxyvitamin D3 (calcitriol; Vit D) prior to administering 5-aminolevulinate (ALA)-based PDT. | Aminolevulinic Acid | vitrin | Mus musculus |
| 2 | The addition of Vit D increased intratumoral accumulation of protoporphyrin IX (PpIX) by 3.3 +- 0.5-fold, relative to mice receiving ALA alone. | Aminolevulinic Acid | vitrin | Mus musculus |
| 3 | Vit D stimulated proliferation (10.7 +- 2.8-fold) and differentiation (9.62 +- 1.7-fold) in tumor cells, underlying an augmented cellular sensitivity to ALA-PDT. | Aminolevulinic Acid | vitrin | Mus musculus |
| 4 | The observed enhancement of tumor responses to ALA-PDT after low, nontoxic doses of Vit D supports a new combination approach that deserves consideration in the clinical setting, and offers potential for improved remission of cutaneous breast cancer metastases. | Aminolevulinic Acid | vitrin | Mus musculus |