Pub. Date : 2015 Jul
PMID : 25708950
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Paradoxical effects of the autophagy inhibitor 3-methyladenine on docetaxel-induced toxicity in PC-3 and LNCaP prostate cancer cells. | Docetaxel | chromobox 8 | Homo sapiens |
| 2 | PC-3 and LNCaP cells were pre-treated with the autophagy inhibitor 3-methyladenine (5 mM) and then exposed to various concentrations (0-100 muM) of docetaxel. | Docetaxel | chromobox 8 | Homo sapiens |
| 3 | Docetaxel produced significant toxicity in PC-3 cells but was not toxic to LNCaP cells. | Docetaxel | chromobox 8 | Homo sapiens |
| 4 | Pre-treatment with the autophagy inhibitor, 3-methyladenine (5 mM) significantly protected PC-3 cells against docetaxel-induced cytotoxicity, increased autophagosome formation and apoptosis measured using monodansylcadaverine, annexin V and caspase-3 fluorescence, respectively. | Docetaxel | chromobox 8 | Homo sapiens |