Title : Clinical impact of concomitant immunomodulators on biologic therapy: Pharmacokinetics, immunogenicity, efficacy and safety.

Pub. Date : 2015 Mar

PMID : 25707965






2 Functional Relationships(s)
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1 Compared to biologic monotherapy, concomitant use of immunomodulators (methotrexate, azathioprine, and 6-mercaptopurine) often increases the systemic exposure of the anti-TNFalpha agent and decreases the formation of antibodies to the anti-TNFalpha agent, consequently enhancing clinical efficacy. Azathioprine tumor necrosis factor Homo sapiens
2 Compared to biologic monotherapy, concomitant use of immunomodulators (methotrexate, azathioprine, and 6-mercaptopurine) often increases the systemic exposure of the anti-TNFalpha agent and decreases the formation of antibodies to the anti-TNFalpha agent, consequently enhancing clinical efficacy. Azathioprine tumor necrosis factor Homo sapiens