Title : Characterization of human cytochrome P450s involved in the bioactivation of tri-ortho-cresyl phosphate (ToCP).

Pub. Date : 2015 Apr 20

PMID : 25706813






2 Functional Relationships(s)
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1 It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may be responsible for this effect as it can irreversibly bind to human butyrylcholinesterase (BuChE) and human acetylcholinesterase (AChE). 2-(ortho-cresyl)-4h-1,2,3-benzodioxaphosphoran-2-one acetylcholinesterase (Cartwright blood group) Homo sapiens
2 It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may be responsible for this effect as it can irreversibly bind to human butyrylcholinesterase (BuChE) and human acetylcholinesterase (AChE). 2-(ortho-cresyl)-4h-1,2,3-benzodioxaphosphoran-2-one acetylcholinesterase (Cartwright blood group) Homo sapiens