Title : Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats.

Pub. Date : 2015 Apr

PMID : 25701797






2 Functional Relationships(s)
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1 Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats. Etoricoxib cytochrome c oxidase II, mitochondrial Rattus norvegicus
2 We studied whether early long-term treatment (17 consecutive weeks starting from 45 days postnatal age) with the non-steroidal anti-inflammatory drug etoricoxib (10 mg/kg/day per os), a selective COX-2 inhibitor, was able to prevent/reduce the development of absence seizures in WAG/Rij rats, a recognized animal model of absence epilepsy and epileptogenesis. Etoricoxib cytochrome c oxidase II, mitochondrial Rattus norvegicus