Pub. Date : 2015 May
PMID : 25701684
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | These immune reactions might be mediated by inflammasomes, macromolecular complexes mounted around the NLRP3 protein and can be activated by reactive oxygen species (ROS) over-generation. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | These immune reactions might be mediated by inflammasomes, macromolecular complexes mounted around the NLRP3 protein and can be activated by reactive oxygen species (ROS) over-generation. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes mediate hyperosmotic stress-induced inflammation in human corneal epithelial cells (HCECs); b) the ROS-NLRP3-IL-1beta axis activation is associated with environment-induced DE. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes mediate hyperosmotic stress-induced inflammation in human corneal epithelial cells (HCECs); b) the ROS-NLRP3-IL-1beta axis activation is associated with environment-induced DE. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes mediate hyperosmotic stress-induced inflammation in human corneal epithelial cells (HCECs); b) the ROS-NLRP3-IL-1beta axis activation is associated with environment-induced DE. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 7 | Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes mediate hyperosmotic stress-induced inflammation in human corneal epithelial cells (HCECs); b) the ROS-NLRP3-IL-1beta axis activation is associated with environment-induced DE. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 8 | Taken together, NLRP3 mediated innate immune responses triggered by rises in ROS generation induce inflammation in hyperosmotic stressed HCECs. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |
| 9 | ROS-NLRP3-IL-1beta signaling pathway might play a priming role in environment-induced DE development. | Reactive Oxygen Species | NLR family pyrin domain containing 3 | Homo sapiens |