Title : Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

Pub. Date : 1989 Sep 15

PMID : 2569930






1 Functional Relationships(s)
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1 In addition, the photolabeling was partially blocked by Adriamycin, vincristine, and colchicine, suggesting that the specific binding sites for verapamil on P-glycoprotein are closely related to the binding sites for these calcium channel blockers and antitumor agents. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens