Title : PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis.

Pub. Date : 2015 May

PMID : 25698787






2 Functional Relationships(s)
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1 Disease pathogenesis is associated with neutrophil accumulation, activation, and oxidative damage, the latter being driven in large part by myeloperoxidase (MPO), which generates hypochlorous acid among other oxidants. Hypochlorous Acid myeloperoxidase Homo sapiens
2 Disease pathogenesis is associated with neutrophil accumulation, activation, and oxidative damage, the latter being driven in large part by myeloperoxidase (MPO), which generates hypochlorous acid among other oxidants. Hypochlorous Acid myeloperoxidase Homo sapiens