Title : Hyaluronic acid-fabricated nanogold delivery of the inhibitor of apoptosis protein-2 siRNAs inhibits benzo[a]pyrene-induced oncogenic properties of lung cancer A549 cells.

Pub. Date : 2015 Mar 13

PMID : 25693888






1 Functional Relationships(s)
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1 Incubation of BaP-challenged cells with AuNP-HA-IAP-2 siRNAs silenced the expression of IAP-2, decreased cell proliferation and triggered pronounced cell apoptosis by the decrease in Bcl-2 protein and the increase in Bax protein as well as the active form of caspases-3. Benzo(a)pyrene BCL2 associated X, apoptosis regulator Homo sapiens