Title : A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro.

Pub. Date : 2015 May

PMID : 25691652






1 Functional Relationships(s)
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1 Molecular modeling demonstrated that the tricyclic ring and methoxybenzene of GRL-0739 have a larger surface and make greater van der Waals contacts with protease than in the case of darunavir. Darunavir nuclear receptor subfamily 3 group C member 1 Homo sapiens