Title : Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes.

Pub. Date : 2015 May

PMID : 25690737






1 Functional Relationships(s)
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1 Contrary to other transporters, NTCP and BSEP were less abundant and active in HepaRG cells, cellular uptake of taurocholate was 2.2- and 1.4-fold and bile excretion index 2.8- and 2.6-fold lower, than in SCHHs and CCHHs, respectively. Taurocholic Acid ATP binding cassette subfamily B member 11 Homo sapiens