Pub. Date : 2015 Sep 15
PMID : 25688715
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Moreover, the combined cytotoxic effect of shikonin and erlotinib was further confirmed with another three EGFR-expressing cell lines, BS153, A431 and DK-MG. Shikonin not only dose-dependently inhibited EGFR phosphorylation and decreased phosphorylation of EGFR downstream molecules, including AKT, P44/42MAPK and PLCgamma1, but also together with erlotinib synergistically inhibited DeltaEGFR phosphorylation in U87MG.DeltaEGFR cells as determined by Loewe additivity and Bliss independence drug interaction models. | shikonin | mitogen-activated protein kinase 3 | Homo sapiens |
2 | Moreover, the combined cytotoxic effect of shikonin and erlotinib was further confirmed with another three EGFR-expressing cell lines, BS153, A431 and DK-MG. Shikonin not only dose-dependently inhibited EGFR phosphorylation and decreased phosphorylation of EGFR downstream molecules, including AKT, P44/42MAPK and PLCgamma1, but also together with erlotinib synergistically inhibited DeltaEGFR phosphorylation in U87MG.DeltaEGFR cells as determined by Loewe additivity and Bliss independence drug interaction models. | shikonin | mitogen-activated protein kinase 3 | Homo sapiens |