Title : Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib.

Pub. Date : 2015 Sep 15

PMID : 25688715






2 Functional Relationships(s)
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1 Moreover, the combined cytotoxic effect of shikonin and erlotinib was further confirmed with another three EGFR-expressing cell lines, BS153, A431 and DK-MG. Shikonin not only dose-dependently inhibited EGFR phosphorylation and decreased phosphorylation of EGFR downstream molecules, including AKT, P44/42MAPK and PLCgamma1, but also together with erlotinib synergistically inhibited DeltaEGFR phosphorylation in U87MG.DeltaEGFR cells as determined by Loewe additivity and Bliss independence drug interaction models. shikonin mitogen-activated protein kinase 3 Homo sapiens
2 Moreover, the combined cytotoxic effect of shikonin and erlotinib was further confirmed with another three EGFR-expressing cell lines, BS153, A431 and DK-MG. Shikonin not only dose-dependently inhibited EGFR phosphorylation and decreased phosphorylation of EGFR downstream molecules, including AKT, P44/42MAPK and PLCgamma1, but also together with erlotinib synergistically inhibited DeltaEGFR phosphorylation in U87MG.DeltaEGFR cells as determined by Loewe additivity and Bliss independence drug interaction models. shikonin mitogen-activated protein kinase 3 Homo sapiens