Title : Synergy between sulforaphane and selenium in the up-regulation of thioredoxin reductase and protection against hydrogen peroxide-induced cell death in human hepatocytes.

Pub. Date : 2012 Jul 15

PMID : 25683399






1 Functional Relationships(s)
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1 Using siRNA to knock down TrxR-1 or Nrf2, sulforaphane (5 muM)-protected cell viability was reduced from 73% to 46% and 34%, respectively, suggesting that TrxR-1 is an important enzyme in protection against hydrogen peroxide-induced cell death. Hydrogen Peroxide latexin Homo sapiens