Title : Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.

Pub. Date : 2015 May

PMID : 25683165






1 Functional Relationships(s)
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1 Sirtuin 6 in turn abrogated the inducing effect of TGF-beta1/H2O2/HOCl on cellular senescence of HCC cells, and was required for the ERK pathway to efficiently suppress the expression of p16 and p21. Hydrogen Peroxide transforming growth factor beta 1 Homo sapiens