Pub. Date : 2015 Mar 15
PMID : 25681335
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this article, we show that TGF-beta1 and IL-10 expression in CTCL cells is regulated by NF-kappaB and suppressed by bortezomib (BZ), which has shown promising results in the treatment of CTCL. | Bortezomib | TSPY like 2 | Homo sapiens |
| 2 | In this article, we show that TGF-beta1 and IL-10 expression in CTCL cells is regulated by NF-kappaB and suppressed by bortezomib (BZ), which has shown promising results in the treatment of CTCL. | Bortezomib | TSPY like 2 | Homo sapiens |
| 3 | In this article, we show that TGF-beta1 and IL-10 expression in CTCL cells is regulated by NF-kappaB and suppressed by bortezomib (BZ), which has shown promising results in the treatment of CTCL. | Bortezomib | TSPY like 2 | Homo sapiens |
| 4 | In this article, we show that TGF-beta1 and IL-10 expression in CTCL cells is regulated by NF-kappaB and suppressed by bortezomib (BZ), which has shown promising results in the treatment of CTCL. | Bortezomib | TSPY like 2 | Homo sapiens |
| 5 | TGF-beta1 suppression decreases CTCL cell viability and increases apoptosis, and adding exogenous TGF-beta1 increases viability of BZ-treated CTCL cells, indicating TGF-beta1 prosurvival function in CTCL cells. | Bortezomib | TSPY like 2 | Homo sapiens |
| 6 | TGF-beta1 suppression decreases CTCL cell viability and increases apoptosis, and adding exogenous TGF-beta1 increases viability of BZ-treated CTCL cells, indicating TGF-beta1 prosurvival function in CTCL cells. | Bortezomib | TSPY like 2 | Homo sapiens |
| 7 | Importantly, our results demonstrate that BZ inhibits expression of the chemokine receptor CXCR4 in CTCL cells, resulting in their decreased migration, and that the CTCL cell migration is mediated by TGF-beta1. | Bortezomib | TSPY like 2 | Homo sapiens |