Title : Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).

Pub. Date : 2015 Mar 15

PMID : 25677663






1 Functional Relationships(s)
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1 Cytotoxicity studies and determination of superoxide (O2(-)) production in the presence and absence of the NOQ1 inhibitor dicoumarol confirmed that the ortho-quinones exerted their antitumor activity through NQO1-mediated ROS production by redox cycling. Quinones NAD(P)H quinone dehydrogenase 1 Homo sapiens