Pub. Date : 2014
PMID : 25674253
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salidroside alleviates paraquat-induced rat acute lung injury by repressing TGF-beta1 expression. | rhodioloside | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | OBJECTIVE: This study was designed to investigate the protective effects of salidroside (SDS) via suppressing the expression of transforming growth factor-beta1 (TGF-beta1) in rat acute lung injury (ALI) induced by paraquat (PQ) and to explore the potential molecular mechanisms. | rhodioloside | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | OBJECTIVE: This study was designed to investigate the protective effects of salidroside (SDS) via suppressing the expression of transforming growth factor-beta1 (TGF-beta1) in rat acute lung injury (ALI) induced by paraquat (PQ) and to explore the potential molecular mechanisms. | rhodioloside | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | OBJECTIVE: This study was designed to investigate the protective effects of salidroside (SDS) via suppressing the expression of transforming growth factor-beta1 (TGF-beta1) in rat acute lung injury (ALI) induced by paraquat (PQ) and to explore the potential molecular mechanisms. | rhodioloside | transforming growth factor, beta 1 | Rattus norvegicus |
| 5 | OBJECTIVE: This study was designed to investigate the protective effects of salidroside (SDS) via suppressing the expression of transforming growth factor-beta1 (TGF-beta1) in rat acute lung injury (ALI) induced by paraquat (PQ) and to explore the potential molecular mechanisms. | rhodioloside | transforming growth factor, beta 1 | Rattus norvegicus |
| 6 | Moreover, SDS reduced the expression of the inflammatory cytokine TGF-beta1 including TGF-beta1 IHC scores (at each time point from 6 to 72 hours after PQ perfusion) and mRNA level (at each time point from 1 to 72 hours after PQ perfusion) compared with PQ groups (P < 0.05). | rhodioloside | transforming growth factor, beta 1 | Rattus norvegicus |
| 7 | Moreover, SDS reduced the expression of the inflammatory cytokine TGF-beta1 including TGF-beta1 IHC scores (at each time point from 6 to 72 hours after PQ perfusion) and mRNA level (at each time point from 1 to 72 hours after PQ perfusion) compared with PQ groups (P < 0.05). | rhodioloside | transforming growth factor, beta 1 | Rattus norvegicus |
| 8 | CONCLUSION: SDS alleviated the pulmonary symptoms of PQ-induced ALI, at least partially, by repressing inflammatory cell infiltration and the expression of TGF-beta1 resulting in delayed lung fibrosis. | rhodioloside | transforming growth factor, beta 1 | Rattus norvegicus |