Title : Nicotine induces resistance to erlotinib via cross-talk between α 1 nAChR and EGFR in the non-small cell lung cancer xenograft model.

Pub. Date : 2015 Apr

PMID : 25670150






2 Functional Relationships(s)
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1 MATERIALS AND METHODS: We identified the role of nicotine to EGFR/AKT/ERK pathways and to erlotinib-resistance in NSCLC PC9 and HCC827 cells by MTS assay and western blot. Nicotine AKT serine/threonine kinase 1 Homo sapiens
2 RESULTS: We confirmed the effects of nicotine on EGFR/AKT/ERK pathways and determined nicotine"s potential in preventing from the effect of erlotinib on NSCLC cells. Nicotine AKT serine/threonine kinase 1 Homo sapiens