Pub. Date : 2015 Mar 1
PMID : 25666822
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands. | Capsaicin | transient receptor potential cation channel subfamily A member 1 | Homo sapiens |
| 2 | Replacement of the benzylamide motif of synthetic capsaicin (nonivamide, 1c) with a tetrazole moiety was detrimental for TRPV1 binding, but unexpectedly generated a potent and non-electrophilic TRPA1 agonist (4a). | Capsaicin | transient receptor potential cation channel subfamily A member 1 | Homo sapiens |
| 3 | These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. | Capsaicin | transient receptor potential cation channel subfamily A member 1 | Homo sapiens |
| 4 | These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. | Capsaicin | transient receptor potential cation channel subfamily A member 1 | Homo sapiens |
| 5 | These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. | Capsaicin | transient receptor potential cation channel subfamily A member 1 | Homo sapiens |
| 6 | These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. | Capsaicin | transient receptor potential cation channel subfamily A member 1 | Homo sapiens |