Title : New insight into the mechanisms of gastroduodenal injury induced by nonsteroidal anti-inflammatory drugs: practical implications.

Pub. Date : 2015

PMID : 25666703






1 Functional Relationships(s)
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1 Dual antiplatelet therapy with ASA and clopidogrel increases the risk of gastrointestinal bleeding in patients with acute coronary syndrome in whom concomitant treatment with a proton-pump inhibitor (PPI) was less effective owing to the interaction of clopidogrel and PPI with the same hepatic cytochrome P-450. Clopidogrel cytochrome P450 family 4 subfamily F member 3 Homo sapiens