Pub. Date : 2015 May 1
PMID : 25659819
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin inhibits the phosphorylation of S6K at nano-molar concentrations in MDA-MB-231 cells; however, micro-molar concentrations of rapamycin are required to inhibit phosphorylation of 4E-BP1 - the phosphorylation of which liberates eIF4E to initiate translation. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |
| 2 | Rapamycin inhibits the phosphorylation of S6K at nano-molar concentrations in MDA-MB-231 cells; however, micro-molar concentrations of rapamycin are required to inhibit phosphorylation of 4E-BP1 - the phosphorylation of which liberates eIF4E to initiate translation. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |
| 3 | Micro-molar doses of rapamycin are required for complete G1 cell cycle arrest - indicating that 4E-BP1 is a critical target of mTOR for promoting cell cycle progression. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |