Title : DNA binding, photoactivated DNA cleavage and cytotoxic activity of Cu(II) and Co(II) based Schiff-base azo photosensitizers.

Pub. Date : 2015 Apr 15

PMID : 25659740






1 Functional Relationships(s)
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1 The Cu(II) and Co(II) complexes interacted with CT-DNA via intercalative mode with the respective Kb value of 3.2x10(4) M(-1) and 2.9x10(4) M(-1) and acted as proficient photocleavers of SC pUC19 DNA in UV-A light, forming (1)O2 as the reactive oxygen species with the quantum yield of 0.38 and 0.36, respectively. Reactive Oxygen Species mitochondrially encoded cytochrome c oxidase II Homo sapiens