Pub. Date : 1989 Jan
PMID : 2565969
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Doxorubicin is a potent inhibitor of interleukin 1 induced cartilage proteoglycan resorption in-vitro. | Doxorubicin | interleukin 1 alpha | Homo sapiens |
| 2 | Since interleukin 1 (IL-1) induces the transcriptional synthesis of enzymes responsible for cartilage resorption it was decided to examine the effects of the antitumour drug, doxorubicin, a DNA transcriptional inhibitor, on alpha IL-1-induced cartilage--resorption in-vitro. | Doxorubicin | interleukin 1 alpha | Homo sapiens |
| 3 | Fine structure of the chondrocytes was preserved by the doxorubicin treatment with IL-1 in contrast to the extensive cellular destruction evident in cartilage treated with IL-1 alone. | Doxorubicin | interleukin 1 alpha | Homo sapiens |
| 4 | [14C]doxorubicin was bound to cartilage proteoglycans, and this effect was promoted by treatment of the cartilage with IL-1. | Doxorubicin | interleukin 1 alpha | Homo sapiens |