Title : Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity.

Pub. Date : 2015

PMID : 25658116






1 Functional Relationships(s)
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1 Furthermore, DNA methylation, which irreversibly deactivates gene transcription, of the insulin promoter, particularly the cAMP response element, is increased in diabetes patients. Cyclic AMP insulin Homo sapiens