Pub. Date : 2015 Jun
PMID : 25656481
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The serotonin system is intimately linked to both the mediation of anxiety and long-term effects of cocaine, potentially through interaction of inhibitory 5-HT2C receptor and gamma-aminobutyric acid (GABA) networks. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |
| 2 | This study characterized the function of the dorsal raphe (DR) 5-HT2C receptor and GABA network in anxiety produced by chronic cocaine withdrawal. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |
| 3 | In a separate cohort of cocaine-injected mice at 25 h of withdrawal, both global and intra-DR blockade of 5-HT2C receptors prior to elevated plus maze testing attenuated anxiety-like behavior. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |
| 4 | This study demonstrates that DR 5-HT2C receptor blockade prevents anxiety-like behavior produced by cocaine withdrawal, potentially through attenuation of heightened GABA activity, supporting a role for the 5-HT2C receptor in mediating anxiety produced by cocaine withdrawal. | Cocaine | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |