Title : A precisely substituted benzopyran targets androgen refractory prostate cancer cells through selective modulation of estrogen receptors.

Pub. Date : 2015 Mar 15

PMID : 25655200






1 Functional Relationships(s)
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1 BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting), and thus adopted a multi-pathway mechanism to exert a more potent anti-proliferative activity against prostate cancer cells than natural and synthetic SERMs. Benzo(a)pyrene AKT serine/threonine kinase 1 Homo sapiens