Pub. Date : 2015 Jun
PMID : 25651816
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ERO1: A protein disulfide oxidase and H2O2 producer. | Hydrogen Peroxide | ER oxidoreductin | Saccharomyces cerevisiae S288C |
| 2 | During this process, protein disulfide isomerase (PDI) chaperones oxidatively fold their client proteins before endoplasmic reticulum oxireductin 1 (ERO1) oxidase transfers electrons from the reduced PDI to the terminal acceptor, which is usually molecular oxygen and is subsequently reduced to H2O2. | Hydrogen Peroxide | ER oxidoreductin | Saccharomyces cerevisiae S288C |
| 3 | During this process, protein disulfide isomerase (PDI) chaperones oxidatively fold their client proteins before endoplasmic reticulum oxireductin 1 (ERO1) oxidase transfers electrons from the reduced PDI to the terminal acceptor, which is usually molecular oxygen and is subsequently reduced to H2O2. | Hydrogen Peroxide | ER oxidoreductin | Saccharomyces cerevisiae S288C |
| 4 | As the oxidative activity of ERO1 is related to the production of H2O2 and consequently burdens cells with potentially toxic reactive oxygen species, deregulated ERO1 activity is likely to impair cell fitness under certain conditions of severe ER stress and may therefore lead to a change from an adaptive to a maladaptive UPR. | Hydrogen Peroxide | ER oxidoreductin | Saccharomyces cerevisiae S288C |
| 5 | As the oxidative activity of ERO1 is related to the production of H2O2 and consequently burdens cells with potentially toxic reactive oxygen species, deregulated ERO1 activity is likely to impair cell fitness under certain conditions of severe ER stress and may therefore lead to a change from an adaptive to a maladaptive UPR. | Hydrogen Peroxide | ER oxidoreductin | Saccharomyces cerevisiae S288C |
| 6 | This review summarizes the evidence of the double-edged sword activity of ERO1 by highlighting its role as a protein disulfide oxidase and H2O2 producer. | Hydrogen Peroxide | ER oxidoreductin | Saccharomyces cerevisiae S288C |