Title : In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids.

Pub. Date : 2015 Apr 20

PMID : 25651456






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In humans, the metabolic bioactivation of pyrrolizidine alkaloids (PAs) is mediated mainly by cytochrome P450 3A4 (CYP3A4) via the hydroxylation of their necine bases at C3 or C8 of heliotridine- and retronecine-type PAs or at the N atom of the methyl substituent of otonecine-type PAs. Nitrogen cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In humans, the metabolic bioactivation of pyrrolizidine alkaloids (PAs) is mediated mainly by cytochrome P450 3A4 (CYP3A4) via the hydroxylation of their necine bases at C3 or C8 of heliotridine- and retronecine-type PAs or at the N atom of the methyl substituent of otonecine-type PAs. Nitrogen cytochrome P450 family 3 subfamily A member 4 Homo sapiens