Title : Effect of opicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity and motor fluctuations in patients with Parkinson's disease.

Pub. Date : 2015 May

PMID : 25649051






3 Functional Relationships(s)
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1 BACKGROUND AND PURPOSE: Opicapone (OPC) is a novel third generation catechol-O-methyltransferase (COMT) inhibitor that enhances levodopa availability. Levodopa catechol-O-methyltransferase Homo sapiens
2 BACKGROUND AND PURPOSE: Opicapone (OPC) is a novel third generation catechol-O-methyltransferase (COMT) inhibitor that enhances levodopa availability. Levodopa catechol-O-methyltransferase Homo sapiens
3 CONCLUSIONS: OPC is a promising new COMT inhibitor that significantly decreased COMT activity, increased systemic exposure to levodopa and improved motor response. Levodopa catechol-O-methyltransferase Homo sapiens