Pub. Date : 2015 Jul
PMID : 25648089
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | There were significant associations between docetaxel-induced leucopenia and 2677G/T of ABCB1 and rs12762549 of ABCC2 (p=0.025 and p=0.028, respectively). | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | In a multivariate analysis, we observed that patients carrying 2677G>T in ABCB1might be associated with higher risk of chemo-resistance when treated with docetaxel (odds ratio [OR], 6.48; confidence interval, 1.92 to 21.94; p=0.003). | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | CONCLUSION: Our data suggest that ABCB1 (2677G/T) and SLCO1B3 (rs11055585) might be major genetic predictors of docetaxel-related toxicities in patients receiving docetaxel chemotherapy. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSION: Our data suggest that ABCB1 (2677G/T) and SLCO1B3 (rs11055585) might be major genetic predictors of docetaxel-related toxicities in patients receiving docetaxel chemotherapy. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |