Title : Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons.

Pub. Date : 2015

PMID : 25647668






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
2 The inhibitory neurotransmitter GABA is synthesized by the enzyme glutamic acid decarboxylase (GAD) in neurons and in pancreatic beta-cells in islets of Langerhans where it functions as a paracrine and autocrine signaling molecule regulating the function of islet endocrine cells. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
3 The inhibitory neurotransmitter GABA is synthesized by the enzyme glutamic acid decarboxylase (GAD) in neurons and in pancreatic beta-cells in islets of Langerhans where it functions as a paracrine and autocrine signaling molecule regulating the function of islet endocrine cells. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens
4 The localization of the two non-allelic isoforms GAD65 and GAD67 to vesicular membranes is important for rapid delivery and accumulation of GABA for regulated secretion. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens