Title : Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor.

Pub. Date : 2015 Apr 1

PMID : 25644539






1 Functional Relationships(s)
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1 Through several lines of evidence, we next documented that adenosine stimulated the mineralization of VICs through a cAMP/protein kinase A (PKA)/cAMP response element-binding protein (CREB) pathway, and found that CREB positively regulated the expression of NPP1 in a positive feedback loop by physically interacting with the promoter. Adenosine cAMP responsive element binding protein 1 Homo sapiens