Title : Cysteine substitution of transmembrane domain amino acids alters the ethanol inhibition of GluN1/GluN2A N-methyl-D-aspartate receptors.

Pub. Date : 2015 Apr

PMID : 25635140






1 Functional Relationships(s)
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1 Molecular modeling identified six residues in the GluN1 TM1 domain (valine V566; serine S569) and the GluN2A TM4 domain (methionine, M817; V820, F821, and leucine, L824) that were in close vicinity to the TM3 F639 residue, and these were individually mutated to cysteine and tested for ethanol inhibition and receptor function. Leucine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens