Pub. Date : 2015
PMID : 25634757
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pioglitazone lowers serum retinol binding protein 4 by suppressing its expression in adipose tissue of obese rats. | Pioglitazone | retinol binding protein 4 | Rattus norvegicus |
| 2 | We investigated whether, and how, pioglitazone modulates serum level of retinol binding protein 4 (RBP4), an adipocytokine associated with obesity and insulin resistance. | Pioglitazone | retinol binding protein 4 | Rattus norvegicus |
| 3 | We investigated whether, and how, pioglitazone modulates serum level of retinol binding protein 4 (RBP4), an adipocytokine associated with obesity and insulin resistance. | Pioglitazone | retinol binding protein 4 | Rattus norvegicus |
| 4 | RESULTS: Pioglitazone treatment significantly decreased serum RBP4 levels in obese rats, which was correlated with reduced body weight and increased insulin sensitivity. | Pioglitazone | retinol binding protein 4 | Rattus norvegicus |
| 5 | Moreover, pioglitazone greatly decreased RBP4 mRNA and protein levels in adipose tissue but not in the liver. | Pioglitazone | retinol binding protein 4 | Rattus norvegicus |
| 6 | CONCLUSION: These results demonstrate that pioglitazone inhibits the level of serum RPB4 by suppressing RBP4 expression in adipose tissue of obese rats, suggesting that inhibiting RBP4 expression in adipocytes may provide a mechanism by which pioglitazone improves insulin sensitivity in insulin-resistant subjects. | Pioglitazone | retinol binding protein 4 | Rattus norvegicus |
| 7 | CONCLUSION: These results demonstrate that pioglitazone inhibits the level of serum RPB4 by suppressing RBP4 expression in adipose tissue of obese rats, suggesting that inhibiting RBP4 expression in adipocytes may provide a mechanism by which pioglitazone improves insulin sensitivity in insulin-resistant subjects. | Pioglitazone | retinol binding protein 4 | Rattus norvegicus |