Title : Lysophosphatidic acid rescues bone mesenchymal stem cells from hydrogen peroxide-induced apoptosis.

Pub. Date : 2015 Mar

PMID : 25633408






1 Functional Relationships(s)
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1 Taken together, our data suggest that LPA rescues H2O2-induced apoptosis mainly by interacting with Gi-coupled LPA3, resulting activation of the ERK1/2- and PI3 K/AKT-pathways and inhibition caspase-3 cleavage, and LPA protection of BMSCs against the apoptosis is independent of it induced autophagy. lysophosphatidic acid AKT serine/threonine kinase 1 Homo sapiens