Pub. Date : 2015 Jun
PMID : 25631750
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin downregulates expression of TGF-betaRII and inhibits proliferation of A549 cells via ERK. | Simvastatin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Our results demonstrated that simvastatin inhibited activation of ERK, downregulated expression of TGF-betaRII, and suppressed A549 cell proliferation. | Simvastatin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Therefore, these results suggest that simvastatin may inhibit A549 cell proliferation and downregulate TGF-betaRII expression by inhibiting activation of ERK. | Simvastatin | mitogen-activated protein kinase 1 | Homo sapiens |