Pub. Date : 2015
PMID : 25628928
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bisphosphonates and statins inhibit expression and secretion of MIP-1alpha via suppression of Ras/MEK/ERK/AML-1A and Ras/PI3K/Akt/AML-1A pathways. | Diphosphonates | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In this study, we found that bisphosphonates and statins inhibited MIP-1alpha mRNA and MIP-1alpha secretion and suppressed extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation by inhibiting Ras prenylation. | Diphosphonates | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | These results indicate that bisphosphonates and statins suppress the Ras/mitogen-activated protein kinase kinase/ERK/AML-1A and Ras/phosphatidylinositol-3 kinase/Akt/AML-1A pathways, thereby inhibiting MIP-1alpha secretion by MM cells. | Diphosphonates | AKT serine/threonine kinase 1 | Homo sapiens |