Title : Activation of Nicotinic Receptors Inhibits TNF-α-Induced Production of Pro-inflammatory Mediators Through the JAK2/STAT3 Signaling Pathway in Fibroblast-Like Synoviocytes.

Pub. Date : 2015 Aug

PMID : 25616906






2 Functional Relationships(s)
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1 Nicotine downregulated production of IL-6 and MCP-1 in RA-FLSs induced by TNFalpha in a concentration-dependent manner, and IL-10 levels were not significantly different after nicotine pretreatment. Nicotine interleukin 6 Mus musculus
2 In conclusion, nicotine has an anti-inflammatory effect on RA by downregulating production of IL-6 and MCP-1 in FLSs, and this is mediated through activation of the JAK2-STAT3 signal pathway. Nicotine interleukin 6 Mus musculus