Title : Pretreatment with pPolyHb attenuates H2O2-induced endothelial cell injury through inhibition of JNK/p38 MAPK pathway by upregulation of heme oxygenase-1.

Pub. Date : 2015 Jun

PMID : 25615876






2 Functional Relationships(s)
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1 Moreover, the inhibition of HO-1 expression by tin porphyrin (SnPP) abolished the protective effects of pPolyHb, which suggested that the cytoprotective effect of pPolyHb involves upregulating HO-1 and subsequently decreasing the phosphorylation of the JNK and p38 MAPK and ROS generation. S-Nitroso-N-propionyl-D,L-penicillamine heme oxygenase 1 Homo sapiens
2 Moreover, the inhibition of HO-1 expression by tin porphyrin (SnPP) abolished the protective effects of pPolyHb, which suggested that the cytoprotective effect of pPolyHb involves upregulating HO-1 and subsequently decreasing the phosphorylation of the JNK and p38 MAPK and ROS generation. S-Nitroso-N-propionyl-D,L-penicillamine heme oxygenase 1 Homo sapiens