Title : All-trans-retinoic acid inhibition of transforming growth factor-β-induced collagen gel contraction mediated by human Tenon fibroblasts: role of matrix metalloproteinases.

Pub. Date : 2015 Apr

PMID : 25614514






3 Functional Relationships(s)
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1 RESULTS: ATRA inhibited TGF-beta-induced collagen gel contraction mediated by HTFs in a concentration- and time-dependent manner. Tretinoin transforming growth factor beta 1 Homo sapiens
2 ATRA also stimulated TIMP-1 release from HTFs in the presence of TGF-beta. Tretinoin transforming growth factor beta 1 Homo sapiens
3 CONCLUSIONS: ATRA inhibited TGF-beta-induced collagen gel contraction mediated by HTFs, likely in part by attenuating the production of MMP-1 and MMP-3 and by stimulating the production of TIMP-1. Tretinoin transforming growth factor beta 1 Homo sapiens