Title : Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin.

Pub. Date : 2015

PMID : 25614218






1 Functional Relationships(s)
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1 We found that the temperature sensitivity of cells in which the conserved Verprolin VRP1 gene had been deleted, which gene is required for actin organization and endocytosis, was suppressed by either FK506 or by cnb1 deletion. Tacrolimus Vrp1p Saccharomyces cerevisiae S288C