Pub. Date : 2015 Feb
PMID : 25613364
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Profilin1, an actin and phosphoinositide binding protein, is downregulated in several adenocarcinomas and it is been shown that its depletion enhances invasiveness and motility of breast cancer cells by increasing PI(3,4)P2 levels at the leading edge. | phosphoinositide-3,4-bisphosphate | profilin 1 | Homo sapiens |
| 2 | We found that loss of profilin1 expression increases the levels of PI(3,4)P2 at the invadopodium and as a result, enhances recruitment of the interacting adaptor Tks5. | phosphoinositide-3,4-bisphosphate | profilin 1 | Homo sapiens |
| 3 | Our results indicate that profilin1 acts as a molecular regulator of the levels of PI(3,4)P2 and Tks5 recruitment in invadopodia to control the invasion efficiency of invadopodia. | phosphoinositide-3,4-bisphosphate | profilin 1 | Homo sapiens |