Title : Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice.

Pub. Date : 2015 Apr

PMID : 25611954






1 Functional Relationships(s)
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1 In particular, we found that SP600125 treatment strongly promoted nonamyloidogenic amyloid precursor protein (APP) processing and inhibited amyloidogenic APP processing via regulating APP-cleavage secretase expression (ie, ADAM10, BACE1, and PS1) in APPswe/PS1dE9 mice. pyrazolanthrone amyloid beta (A4) precursor protein Mus musculus