Title : The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding.

Pub. Date : 2015 Mar 20

PMID : 25605720






1 Functional Relationships(s)
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1 However, chimeras with the extracellular domain of ADAM10 and the transmembrane domain of ADAM17 with or without the cytoplasmic domain of ADAM17 show reduced stimulated shedding of the ADAM10 substrate betacellulin, whereas the ionomycin-stimulated shedding of the ADAM17 substrates CD62-L and TGFalpha is not affected. Ionomycin ADAM metallopeptidase domain 10 Homo sapiens